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KMID : 0931320040040020040
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대한상부위장관.헬리코박터학회지
2004 Volume.4 No. 2 p.40 ~ p.46
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Association of Polymorphism of IL-10 and TNF-A Genes with Gastric Cancer in Korea
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Lee Ja-Young
Kim Hak-Yang
Kim Kyoung-Ho
Kim Seong-Man
Lee Jun-Ho
Jang Myoung-Kuk
Park Joon-Yong
Lee Jin-Heon
Kim Jin-Ho
Yoo Jae-Young
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Abstract
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Background/Aims: We performed this study to determine the role of polymorphisms of the IL-10 and TNF-α promoter genes in the carcinogenesis/ pathogenesis of gastric cancer (GC) in Korea.
Methods: A total of 232 patients with GC (n=122), gastric ulcer (GU)(n=58), and duodenal ulcer (DU) (n=52) were enrolled and 120 healthy controls were included. Polymorphisms of IL-10- 1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP.
Results: There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with GC or PUD and control group. In addition, there was no difference in genotypic frequencies according to the H. pylori infection status and histologic type of GC.
Conclusions: In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2004;4:40-46)
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KEYWORD
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Gastric cancer, Interleukin-10, Tumor necrosis factor-alpha, Polymorphism, Helicobacter pylori
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